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The Roman encyclopedist Celsus, in his De Medicina of ca.

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30 AD, suggested willow leaf extract to treat the four sns of inflammation: redness, heat, swelling and pain.

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Willow treatments also appeared in Dioscorides's De Materia Medica, and Pliny the Elder's Natural History.The word Aspirin was Bayer's brand name, rather than the generic name of the drug; however, Bayer's rhts to the trademark were lost or sold in many countries.


By the time of Galen, willow was commonly used throughout the Roman and Arab worlds, The major turning point for salicylate medicines came in 1763, when a letter from English chaplain Edward Stone was read at a meeting of the Royal Society, describing the dramatic power of willow bark extract to cure ague—an ill-defined constellation of symptoms, including intermittent fever, pain, and fatue, that primarily referred to malaria.

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